Pd-1/Pd-L Pathway: Its Preclinical Rationale and Clinical Application in Lymphoid Neoplasm’s

Nahla A M Hamed*

DOI: 10.26717/BJSTR.2017.01.000159

Received: June 26, 2017   Published: June 29, 2017

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Abstract

The PD-1/PD-L1 pathway plays an important role in mediating immune tolerance in physiological stateand is an important mechanism by which malignancies can evade the host immune response. PD-1 inhibitors may be particularly attractive for hematologic malignancies because the activation of adoptive immunity has been proven effective in the form of allogeneic stem cell transplantation. Clinical trials of anti-PD-1 monoclonal antibodies have demonstrated promising results in lymphoma patients with advanced disease.

Abbreviations: PD-1: Programmed Death-1; FL: Follicular Lymphoma; CHL: Classical Hodgkin Lymphoma; BL: Burkitt Lymphoma; DLBCL: Diffuse Large B-Cell Lymphoma; PI3K: Phosphatidylinositol-4,5-Bisphosphate 3-Kinase; PTEN: Phosphatase And Tensin Homologue; PCNSL: Primary Central Nervous System Lymphoma; PTL: Primary Testicular Lymphoma; HRS: Hodgkin And Reed-Sternberg; TCL: T-Cell Lymphomas

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