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Research ArticleOpen Access

Polymorphisms in the Vitamin D Receptor Gene and Risk of Autoimmune Liver Diseases: A Meta-Analysis

Volume 9 - Issue 3

Xiaoguang Wang1, Xiaodan Yang1, Fei Chen1, Wei Chen*2, and Zheng xiang Zhong*1

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    • 1 Jiaxing Second Hospital, Zhejiang Province, China
    • 2 Cancer Institute of Integrated traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, China

    *Corresponding author: Zheng-Xiang Zhong, The Second Affiliated Hospital of Jiaxing University, China Wei Chen, Zhejiang Academy of Traditional Chinese Medicine, China

Received: September 18, 2018;   Published: October 03, 2018

DOI: 10.26717/BJSTR.2018.09.001815

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Vitamin D Receptor (VDR) polymorphisms have been investigated in the context of some autoimmune liver diseases, such as primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH). However, the association between VDR and autoimmune live diseases is still controversial and ambiguous. Hence, we integrate previous finding and explore whether this polymorphism is associated with susceptibility to autoimmune liver diseases. A meta-analysis was performed by Pubmed, Ovid, Medline, and Web of science databases, with the last report up to February 2012. Case-control studies containing available genotype frequencies of VDR were chose. The odds ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of association. A total of 6 publications containing 9 studies (7 studies about VDR, 2 studies about AIH) including 844 cases and 1,522 controls were identified. The combined results based on all studies showed that there was a statistically significant link between Apa1 and autoimmune liver diseases (OR=0.85, 95%CI 0.74-0.96, P=0.058, for a vs. A; OR=0.75, 95%CI 0.58-0.97, P=0.212, for aa vs. AA; OR=0.78, 95%CI 0.63-0.98 P=0.235, for Aa vs. AA; OR=0.77, 95%CI 0.63-0.94, P=0.231, for Aa+aa vs. AA), while the Bsm1 and Taq1 don’t show the association with autoimmune liver diseases. The current meta-analysis shows that based on current evidence from published studies Apa1 may be a low-penetrant risk factor for autoimmune liver diseases.

Keywords: VDR (Apa1, Bsm1, Fok1, Taq1) Polymorphism; Autoimmune Liver Diseases; Primary Biliary Cirrhosis (PBC); Autoimmune Hepatitis (AIH); Meta-Analysis

Abstract | Introduction | Methods | Results| Discussion| Acknowledgment| References|