Research ArticleOpen Access

Correlation of Reduced Glutathione with Brest Cancer Using High Performance Liquid Chromatography

Volume 1 - Issue 5

**Mufeed Jalil Ewadh¹* Ali Mohammed Jawad² and Alaa Sadiq Al awad¹**

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- ¹College of Medicine, University of Babylon, IRAQ
- ²Food Contamination Research Center, Directorate Environment and Water Technology, IRAQ
*Corresponding author: Mufeed Jalil Ewadh, College of Medicine, University of Babylon, Hilla, IRAQ

Received: September 24, 2017 Published: October 10, 2017

DOI: 10.26717/BJSTR.2017.01.000421

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Abstract

Breast cancer (BC) is a type of malignancy appeared in breast tissue, occurs in both premenopausal and also in postmenopausal women’s. Glutathione (GSH) is a tripeptide that is found intracellularly in high concentration, being the most abundant low molecular mass thiol. A total of 80 patient with (BC) divided in two groups, first group (n=40) women with breast cancer without chemotherapy, second group (n= 40) women with breast cancer with chemotherapy. The control group (n= 40) apparently healthy women’s matched with patient group. Women with (BC) have a significant lower serum level of (GSH) than those who are not diseased and even than those who received chemotherapy (p˂ 0.05). So, this lead to a conclusion that; breast cancer women have low level of GSH and increased upon administration of chemotherapy. The objective of this study is to assess GSH status in women’s BC receiving chemotherapy treatment.