Lisfranc fractures present unique challenges to surgeons due to the complex anatomy and small irregular bone structures where fracture reduction and realignment must be precise to achieve an optimal result for the patient. The choice of surgical technique, internal fixation used, and choice of bone graft (if fusion is required) are key aspects to consider for successful treatment. The following case describes a complicated Lisfranc fracture in a morbidly obese women where TMT fusion and ORIF were achieved with plate and screw fixation and a latest generation silicated calcium phosphate bone graft. The surgery resulted in complete pain relief, anatomical fracture reduction, and correction of alignment in the Lisfranc complex.