"Premature Rupture of Membranes: Associated with Twin Pregnancy"

Dagoberto Benítez Díaz1, William Andrés Jaramillo Cabrera2, Vanessa de Jesús Burgos Doria3, Fabio Enrique Pacheco Londoño4, Tatiana Betancur Pérez5, Jhenny Rubiano Ruiz6, Laura Maria Osorio Ospina7 and Fernan Piñeres Vanegas8 1General Physician, Universidad del Sinú, Colombia 2General Physician, Universidad Libre, Cali, Colombia 3General Physician, University of Norte, Colombia 4General Physician, Universidad Cooperativa de Colombia, Colombia 5General Physician, Universidad Metropolitana, Colombia 6Fourth-Year Physician Student, Universidad Pedagogica y Tecnologica de Colombia, Colombia 7General Physicia, Universidad Remington, Colombia 8Intern Physician, Universidad Metropolitana Barranquilla, Colombia


Introduction
The routine control of a pregnant woman is increasingly The amniotic or ovular membranes appear in a strict maternalfetal relationship from 14-15 weeks and are the only barrier that exists in the third trimester between the external environment and the product, they have very important and particular functions such as protecting and containing amniotic fluid at adequate levels so that the pregnancy remains viable, in the case of a rupture the amniotic fluid begins to come out, causing oligohydramnios which in many cases can end in the termination of pregnancy, it also plays an important role in the electrolyte transport and exchange and decreases bacterial growth. Twin gestation is a condition constantly observed in our population, the recognition of recent evidence that relates twin gestation and the appearance of PROM allows the development of prevention strategies and necessary measures to prolong the gestation period and avoid preterm delivery.

Materials and Methods
A bibliographic search was carried out that spanned from 2017 to 2021 in the databases PubMed, Elsevier, scielo, Update, Medline, national and international libraries. We use the following descriptors: premature rupture of membranes, premature delivery, twin pregnancy, premature labor. The data obtained oscillate between 16 and 60 records after the use of the different keywords.
The search for articles was carried out in Spanish and English, it was limited by year of publication and studies between 2017 and 2021 were used. The main exclusion criteria were articles that had more than 5 years of publication.

Results
The cause of premature rupture of membranes at the limit of fetal viability (after 24 weeks of gestational age) is varied, having as risk factors cervical incompetence, the use of cerclage, tobacco consumption, history of preterm delivery and / or rupture of membranes in previous pregnancies, decreased body mass index, low socioeconomic status, presence of bleeding in the second and third trimesters, nutritional deficiencies, uterine over-attendance due to polyhydramnios or twin pregnancy. Localized infections in external components such as the cervix, or internal intrauterine structures can cause loss of continuity of the ovular membranes [1]. Twin pregnancy, defined as the gestation of two fetuses within the uterus, is associated with a higher probability of maternalfetal complications, a 3-fold higher risk of pre-eclampsia, preterm delivery, premature detachment of the placenta, pyelonephritis, postpartum hemorrhage, and premature rupture of membranes [2].
The cause of this obstetric-gynecological condition is unknown, but it is associated with multiple pathologies causing 25-30% of premature births, which is why it is considered the main cause of prematurity and maternal mortality. Over the years, findings have been mentioned in areas of rupture that show extremely altered points of morphology: collagen II deficiency, edema with deposits of fibrinoid material, thinning of the trophoblastic and decidual layers and the development of contractions due to the presence of deposits. of prostaglandins E2 and F2, product of decidual cells and the presence of bacteria [3].
This prelude to a neonatal emergency brings severe consequences and complications such as: chorioamnionitis, neonatal sepsis due to colonization of microorganisms in the amniotic fluid, prematurity and even fetal death. It is characterized by having an affinity for women at the extremes of childbearing age, a prevalence in women with comorbidities and a significant history of abortions (spontaneous or induced), and high levels of morbidity and mortality due to prematurity in multiple or twin pregnancies [4]. The relationship between twin pregnancy and PROM has not been demonstrated, however it is related to an estimated incidence of 5-8% according to the WHO. Representing the premature rupture of membranes 3% in Newborns as a result of twin pregnancies and 12% of perinatal deaths [5].
As the incidence of twin pregnancy increases, there are numerous complications associated with perinatal morbidity and mortality. One of the factors that could possibly affect and impact the most is obesity; the elevated body mass index typical of twin pregnant women was associated with a higher risk of premature rupture of the membranes, associated with uterine over-attendance; myometrial distention increases myometrial contractility, releases prostaglandins, and positively regulates oxytocin receptors, which are involved in the cascade of events that have been identified in the development of PROM [6]. Through this thematic review, it was shown that premature rupture of membranes has a very significant incidence during the development of a twin pregnancy and implies a significant cause of perinatal morbidity and mortality. In order to cope with this problem, it is important to know the risk factors that predispose to this disease, as well as the possible complications that can develop depending on the management. The diagnosis is fundamentally clinical, which is why it is of the utmost importance to carry out an adequate clinical history that allows the patient's symptoms and signs to be concisely established and, depending on the case, complementary diagnostic tests can be added to help clarify the clinical picture if there are doubts [4][5][6].

Discussion
Over the past 25 years, the rates and numbers of twin and higher-order births in the United States have increased at an unprecedented rate [7]. As the incidence of twin pregnancy increases, it is also observed that both maternal and perinatal complications increase, associated with perinatal morbidity and mortality [8]. Currently, recent evidence is recognized that relates this obstetric circumstance with the appearance of premature rupture of membranes, so determining its association in our environment allows us to develop prevention strategies and adopt necessary measures with those pregnant women with a greater probability of developing rupture of the membranes. membranes with a reduction in the risk that this implies for the mother-fetus binomial.
Markus L et al. in Tanzania in 2013 who recognized the association between twin gestation and the risk of developing premature rupture of membranes, in a retrospective cohort study observing that the frequency of premature rupture of membranes was 11% in the exposed group. twin gestation and only 4% in the single gestation group (p <0.05) [9]. The study by Vogel