Treatment of Pelvic Organ Prolapse with “Vaginal Laser”– A Mini-Review of the Literature

The pelvic organ prolapse (POP) is a common condition of women at any age and affects the quality of life negatively. The technology that is known as “laser treatment” has been used more often recently as a part of studies to treat POP. In this paper we reviewed the databases (PubMed, Google Scholar, and Web of Science) for published literature about the use of laser treatment of POP in women and identified relevant-papers. of Pelvic Organ Prolapse with La ser”– A Mini-Review the


Introduction
It is not yet possible to prevent the aging processes. Like other several risk factors (such as genetics, race/ethnicity, gender, obstetrical and gynaecological injuries, smoking, obesity) the aging also causes weakening of the pelvic floor connective tissue/ collagen and leads to pelvic organ prolapse (POP) [1]. Although the exact prevalence of the pelvic organ prolapse of women is unknown, this condition was reported up to 50 percent in some studies [1]. Most women having a POP, often complain of a pressure sensation respectively a bearing-down sensation [2]. The POP impairs further, as a consequence of its impact on bladder, bowel function and the sexual function, hence impacts the quality of life negatively [3]. The prolapse of pelvic organs can be treated either conservatively or surgically, each with its own advantages and disadvantages. Treatment with pessaries and the initiation of pelvic floor physical therapy with or without estrogens are the usual effective conservative treatment options for POP of women [4,5]. Surgical treatment is the other alternative for qualified cases. Surgery requires experience and can require more effort and it may cause more complications. The laser treatment is getting increasingly popular in the field of urogynaecology as an alternative option, following its adoption from dermatology and plastic-surgery. The motto of this procedure is the reversal of aging "rejuvenation". In this paper we reviewed the literature for the use of laser for POP in women.

Vaginal Laser Technology
The laser light energy induces a controlled injury by means of thermal or ablative effect at the superficial tissue level [6,7].
Microablative fractional CO2 and Er: YAG (erbium-doped yttrium aluminium garnet) lasers are two introduced systems to treat genitourinary conditions. Two technologies differ from each other in terms of their acting principals and varying wavelengths. The absorbed waves in the tissue leads to an expected tissue reaction.
Microablative fractional CO2 laser creates superficial microablation zones on the mucosal surface. In contrast to CO2 laser creates Er:YAG laser rapid sequential heat pulses, which are transferred into the mucosa. The fast heat pulse does not injure the tissue surface [8].
Hypothesized as "tissue remodelling" showed by Gaspar, et al. in

Laser in Gynaecology/Urogynaecology
The laser technology has been widely used in gynaecology for more than 40 years after Holmquist et al. first introduced the use of laser in vaginal surgery in the 1970s [12]. US Food and Drug Administration (FDA) licenced the laser systems for "incision, excision, ablation, vaporization and coagulation of body soft tissues [7]. Other than this indications, laser is increasingly being used for the treatment of vaginal atrophy, urinary incontinence, vulvodynia, lichen sclerosus and vaginal laxity syndrome. However but there's still lacking good-quality evidence and long term follow-up studies [13][14][15].

Laser Treatment for Pelvic Organ Prolapse of Women
Collagen maintains the supportive functions of the pelvic floor and is one of the most important components of the extracellular matrix in connective tissue. Jackson et al. presented a hypothesis to explain the mechanism for genitourinary prolapse on a molecular level. They showed that genitourinary prolapse is associated with a reduction in total collagen content and a decrease in collagen solubility [16]. The Hypothesis is that the prolapse would be improved after a laser treatment was related to the reality of "tissue remodelling" with laser injury. Just a few studies in the literature discussed the laser treatment for POP as a primary endpoint. Ogrinc  showed improvement of two POP-Q stages). The type of prolapse in this study was not clearly defined [20]. Athanasiou et al. showed in a current study that no improvement for POP in a randomised, single-blind study with Er:YAG laser treatment [21]. The authors results. The longest follow up was limited to 36 months [17]. That frustrates also us to speak about long-term effects of laser. The two discrepant studies [18,21] also show us that the age of the patient, observing time and treatment frequency matters. The treatment modalities should be that's why improved/individualized. Ogrinc et al. commented also on this study and attributed the discrepancy to the study design [23]. No major adverse effect is reported eventually for laser treatment by POP. A large observational 8 years follow up study which aimed to show the safety of Er:YAG laser may also supports this finding [24].

Conclusion
As seen above although the literature is hopeful there's still lacking data on the safety and the effectiveness of laser treatment in POP. That's why issued FDA in 2018 states a warning concerning effectiveness and safety of laser treatment for urinary incontinence, vaginal "rejuvenation" or cosmetic vaginal procedures [7]. The published studies are leading and lightening the scientific way. That should motivate the clinicians to design better planned randomised and controlled prospective studies to understand the effect of the laser treatment by POP in woman. We believe that laser treatment will soon be used and recommended as an alternative, minimally invasive treatment method for low grade POP.

Conflict of Interest
There are no conflicts of interest with regard to this publication.

Funding
No funding.