Self-Cholesterol Measuring Devices Mission and CardioChek: Total Cholesterol, Triglycerides, High Density Lipoprotein (HDL)-Cholesterol Estimations in Whole Blood Samples

on the CardioChek the ABSTRACT Self-monitoring of blood lipids has been described as very important in the management of the patients with raised blood lipids. There are a number of self-monitoring blood lipid devices such as the Mission ACON and the CardioChek PA. They measure a number of lipid fractions: total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and ratios on whole blood, plasma or serum. Both devices have been shown to meet most of the criteria of analytical acceptability by the National Cholesterol Education Program (NCEP) guidelines. We compared the performance of the Mission and CardioChek lipid testing devices to determine lipid profile (total cholesterol, HDL-cholesterol and triglycerides) in whole blood samples from healthy volunteers. The total cholesterol estimates of both devices showed good correlation (r=0.83), with the Mission’s estimates being significantly higher than CardioChek estimates, on average by 1.29 mmol/L (22.4%). The HDL-cholesterol estimates of both devices showed good correlation (r=0.87), with the Mission’s estimates being significantly higher than the CardioChek estimates, on average by 0.16 mmol/L (7.6%). The triglyceride estimates of both devices showed very good correlation (r=0.99), with the Mission’s estimates being slightly lower than the CardioChek estimates, on average by 0.08 mmol/L (15.9%).


Introduction
Hyperlipidemia is considered a primary and independent risk factor for cardiovascular disease. The monitoring of the blood lipids has been considered very important in the management of the disease. Self-monitoring of blood lipids has been described as very important in the management of the patients with raised blood lipids. There are a number of self-monitoring blood lipid devices such as CardioChek PA and Mission ACON. They measure a number of lipid fractions (total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein) and ratios on whole blood, plasma or serum collected from the finger or venous blood using reflectance or biosensor technology with single-use, disposable, dry reagent test strips, rotors or cassettes. The Mission ACON has recently been described to meet most of the criteria (precision, accuracy and total analytical error) of analytical acceptability by the NCEP guidelines [1]. The CardioChek has been described to show reasonable compliance with NCEP guidelines for coefficient of variation and bias measurements [2,3]. It's measurements (total cholesterol, HDL -cholesterol, triglycerides and LDL -cholesterol) have shown good clinical agreement and correlation with reference laboratory analysers [4,5].
We have previously shown that total cholesterol estimations have been lower on the CardioChek device compared with the

ARTICLE INFO ABSTRACT
Self-monitoring of blood lipids has been described as very important in the management of the patients with raised blood lipids. There are a number of selfmonitoring blood lipid devices such as the Mission ACON and the CardioChek PA. They measure a number of lipid fractions: total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and ratios on whole blood, plasma or serum. Both devices have been shown to meet most of the criteria of analytical acceptability by the National Cholesterol Education Program (NCEP) guidelines. We compared the performance of the Mission and CardioChek lipid testing devices to determine lipid profile (total cholesterol, HDL-cholesterol and triglycerides) in whole blood samples from healthy volunteers. The total cholesterol estimates of both devices showed good correlation (r=0.83), with the Mission's estimates being significantly higher than CardioChek estimates, on average by 1.29 mmol/L (22.4%). The HDL-cholesterol estimates of both devices showed good correlation (r=0.87), with the Mission's estimates being significantly higher than the CardioChek estimates, on average by 0.16 mmol/L (7.6%). The triglyceride estimates of both devices showed very good correlation (r=0.99), with the Mission's estimates being slightly lower than the CardioChek estimates, on average by 0.08 mmol/L (15.9%).
estimations made using the Mission device [6]. In addition, there has been a report which compared the cholesterol estimations from Mission and CardioChek devices to a reference method, the cholesterol estimations from both devices showed similar agreement to the reference method [7]. In this short report, we have compared both the performance of the Mission ACON and CardioChek PA in measuring lipid profile (total cholesterol, HDLcholesterol and triglycerides) in whole blood samples from healthy volunteers.

Descriptive Analysis
The Mission's total cholesterol (TC) estimates ranged between

Total Cholesterol
The

HDL-Cholesterol
The

Declaration of Conflicting Interests
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding
The author(s) received no financial support for the research, authorship, and/or publication of this article.

Credit Author Statement
S Clark (study analysis, review and editing), J Bolodeoku (writing original draft, supervision). The authors will like to thank Sarah Christie for final editing and review of the manuscript.