Nasal Mask: An Alternative to Prevent Contagion during Essential Activities

Introduction: One of the main routes of transmission of SARS-CoV-2 is through the nostrils. The virus binds to the ACE2 cellular receptor facilitating its spread to the Central

person coughs, sneezes, or speaks [4]. Most of these particles fall at a distance less than one meter from the emitter. However, if they are forcefully ejected, they can travel more than two meters. SARS-CoV-2 has four structural proteins: Spike (S-protein), Nucleocapsid (N-protein), Membrane (M-protein), and Envelope (E-protein).
For the virus to infect the host cell, the S-protein must bind to the angiotensin-converting enzyme 2 (ACE2) receptor. This binding triggers a structural change in the S-protein, allowing further binding to the cell membrane to release its genetic material into the cytoplasm and start the viral replication cycle [5,6]. The virus transmission can occur through three different routes: ocular, nasal, and oral ( Figure 1). One of the main routes of infection occurs through the nasal cavity, which contains three types of epithelia: scaly, respiratory, and olfactory. Olfactory epithelium cells express the highest levels of ACE2 proteases and transmembrane protease, serine 2 (TMPRSS2), necessary for infection [6]. Mouth, and its entry into the CNS through olfactory nerve endings, binding to ACE2 receptors. Designed with BioRender. com.
Once the virus is inside the olfactory epithelium cells, it spreads to the olfactory bulb, passing through the cribriform plate and reaching the meninges and cerebrospinal fluid (CSF), which serves as a vehicle for its spread into the central nervous system (CNS). SARS-CoV-2 has already been detected in this tissue [6].
Through the nerve and the olfactory bulb, the virus travels using a transsynaptic pathway. It can reach the brain stem, affecting the respiratory center, leading to acute respiratory distress syndrome (ARDS), which is the leading cause of death in patients with Covid-19 [6,7]. In addition to infection through the olfactory nerve and CSF, SARS-CoV-2 can access the CNS by hematogenous dissemination because it infects endothelial cells in blood vessels reaching any organ [8]. On the other hand, the conjunctiva is a site of direct inoculation. Infected secretions and tears are transported through the nasolacrimal duct and drained into the nasopharynx, leading to lower respiratory tract infection [9]. Considering the SARS-CoV-2 spreading mechanisms, global organizations have implemented effective protective measures. Mandatory use of face masks has been implemented for all people 2 years of age and older.
Masks must be worn in public places and transport of any kind covering the nose, mouth and secured under the chin [10].
Various types of face masks have been designed, for instance, N95s with three structural layers and KN95s that consist of four layers. Both types retain particles up to 0.3 microns with 95% efficiency, so they are recommended for healthcare personnel [4].
Even though face masks protect the oral and nasal pathways, there are daily activities, such as eating or drinking, that force the masks to be removed in public or crowded places, leaving exposed two of

Material and Methods
Different prototypes were developed using various materials

Results
The nasal protector consisted of the body

Adjustable Nasal Strap
Made of any suitable material, preferably aluminum. When used, it can be folded in the direction of the nose and adjusted to its shape, reinforcing the body's sealing.

Fold
Allows the correct fit to the nose's shape and the passage of air for breathing.

Clamping Bands
They are located in pairs at each end side of the body. They can be worn on the ears, but they can also be tied behind the head to fix the body. They can be elastic and adjustable, made of any material that ensures correct gripping and facial sealing, avoiding leaks around the nose. Length: 11.5cm, separation between parallel lines: 1cm. The nasal mask's final structure allows the air to pass from the interior space of the protector to the outer space of the same and vice versa, retaining any particles or sprinkling dispersed in the air that may contain an infectious or polluting agent (Figure 4).

Discussion
The use of the nasal masks aims to keep the nose protected, which prevents the virus from entering and easily invading the CNS through the bulb and olfactory nerve, causing neurological alterations, such as strokes, epilepsy, and encephalitis, which have already been documented [6]. The nasal mask does not intend to displace face masks, nor will it prevent the disease. The nasal mask should also be used in combination with other barrier devices, such as face shields, conventional face masks, lenses, or googles to provide double protection. When the oral cavity is needed free to eat, drink or receive Stomatological treatment, the nose will be protected, and thus the virus will not enter through this route.
Besides, its use does not interfere with the palatability of food and allows adequate ventilation when used alone or in combination with other protective barriers. The nasal mask is a protective measure that benefits the entire population, including patients with comorbidities (systemic hypertension, diabetes, obesity) and older adults, who are more prone to suffer complications from COVID-19 due to their risk factors.

Conclusion
The nasal mask is a device whose function is to prevent the entry of infectious microorganisms. It is also a protective measure that reduces the risk of contagion for patients who go to dental offices, people dining in restaurants when actively eating or drinking, and passengers eating meals during long-duration flights, among others. This nasal mask will allow to reactivate the economy and perform any productive activity. It is essential to mention that it is not intended to displace the face mask. As with any other mask, for its proper use, it is crucial to perform a correct hand washing, check the material integrity, avoid touching it during use, and store it in a plastic bag after removing it. The amount of time a mask can be used will depend on the type of constituent materials.