Can Lactobacillus sp. Prevent Alone Recurrent Non-Complicated Urinary Tract Infection?

infection. studies published describing the relationships between bacterial vaginosis and lactobacilli The host predisposing and genetic factors have been proven to alter vaginal microbial composition, the disrupted vaginal ecosystem often resulting in a disease state and symptomatic vaginitis. Meanwhile, Lactobacillus have shown to possess potential health benefits and restoration of healthy microflora and The Lactobacillus -dominated vaginal flora in premenopausal women impedes colonization with uropathogens due to competitive exclusion and maintaining low vaginal pH While the concept of probiotics seems to be simple ABSTRACT As microbiologists or clinical doctors, in daily practice, we assist to cases of recurrent urinary tract infection in women. They appear despite a correct antibiotic regimen recommended by the physicians and correctly followed by the patients. In this mini review, we set to investigate the existing medical literature in order to find if Lactobacillus sp. could, alone, prevent the non-complicated urinary tract recurrences.


Mini Review
At least once in their lifetime, no matter what age, approximately 50% of women are confronting with non-complicated UTI, and 20-30% of them are facing recurrences [1]. RUTI is commonly defined as at least two episodes of specific symptoms associated with pyuria or positive bacterial culture in the past six months or three infections in the last twelve months. A major problem the physicians have to deal with is the antimicrobial resistance as consequence of excessive use of antibiotics in human and veterinary medicine, meaning that the effective antibiotics panel is diminishing [2]. The literature we have examined correlates the already known relation between UTI, RUTI, and microbiological charge of perianal, perineal, vulvovaginal and periurethral areas.
Starting from perianal area, the uropathogenic bacteria are carriedout to the perineal zone, and periurethral tissues, possibly causing vaginosis, vulvovaginitis, and/or cystitis. This carriage is related to many factors, such as incorrect behavior regarding intimate hygiene, the sexual habits, and the use of spermicides [3,4]. The role of lactobacilli in the maintenance of vaginal health was first recognized by Döederlein in the late 18 th century, the concept of administering exogenous Lactobacillus for maintaining optimal vaginal microflora being more than a century old. vaginal pH [7]. While the concept of probiotics seems to be simple

ARTICLE INFO ABSTRACT
As microbiologists or clinical doctors, in daily practice, we assist to cases of recurrent urinary tract infection in women. They appear despite a correct antibiotic regimen recommended by the physicians and correctly followed by the patients. In this mini review, we set to investigate the existing medical literature in order to find if Lactobacillus sp. could, alone, prevent the non-complicated urinary tract recurrences. in some ways, the critical issues include the selection of the optimal strains, verification of the necessity for, and mechanisms of, certain factors in the interference with pathogens and clinical proof that there is merit to the theory. Lactobacilli produce hydrogen peroxide, increasingly recognized as essential components of a healthy microflora environment, also being a toxic compound to many microorganisms at concentrations that are typical in the vaginal fluid, providing an intrinsic protective mechanism in the vagina [8].

Results
Studies using Lactobacillus-containing products such as For the therapy assessment of UTI, there are double-blind trials (with one placebo-controlled), follow-up ranging from six months to one year. Therefore, one out of four trials reported a 73% reduction in episodes of recurrent UTI compared with the previous year in both studied groups; the other three studies found no beneficial effects of Lactobacillus-containing probiotics on recurrence of UTI. Also, five trials reported that Lactobacillus therapy was well tolerated based on the absence of discontinuations and either an absence of adverse events or a similar number of adverse events between groups [5].
It is proved that most UTIs are caused by intestinal bacteria that ascend through the urethra to the bladder and, sometimes, kidneys [12]. Specific lactobacilli strains can interfere with the adherence, growth, and colonization with uropathogenic bacteria, reducing the risk of ascent into the bladder [13]. There are only a few studies characterizing the vaginal Lactobacillus species in healthy women of reproductive age in India. More studies in India are warranted as the species distribution in Indian women may be different.
This would raise the question on the necessity in a probiotic of a single species or a balanced mixture depending on the local flora [14].

Discussion
Currently, the available literature indicates no strong evidence about efficiency of using lactobacilli as unique therapy in prevention of RUTI, but considering their benefits for the gut,

Conclusion
Considering their so many beneficial properties, lactobacilli are promising as adjuvant therapy for vaginal infection to prevent UTI and RUTI. There is a need of larger randomized trials, with welltargeted patients and methods, aiming to find a non-antibiotic prophylaxis for UTI and RUTI.