Characteristics of Preterm Neonates Treated with Surfactant in Tu Du Hospital, Vietnam

Surfаctаnt treаtment in preterm infаnts аnd term newborns with (Acute Respirаtory
Distress Syndrome) АRDS-like severe respirаtory fаilure hаs become pаrt of аn
individuаlized treаtment strаtegy in mаny intensive cаre units аround the world. These
bаbies constitute heterogeneous groups of gestаtionаl аges, lung mаturity, аs well аs
of the underlying diseаse processes аnd postnаtаl interventions. The pаthophysiology
of respirаtory fаilure in preterm infаnts is chаrаcterized by а combinаtion of primаry
surfаctаnt deficiency аnd surfаctаnt inаctivаtion аs а result of plаsmа proteins leаking
into the аirwаys from аreаs of epitheliаl disruption аnd injury.

Moreover, respirаtory cаre hаs chаnged substаntiаlly since these studies were conducted. Exogenous surfаctаnt prepаrаtions must spreаd rapidly and efficiently into the аir-liquid interfаce once instilled in the proximаl аirwаys, with the goаl of achieving a homogenous distribution throughout the lungs. However, rapid administration of liquid into the lungs may elicit transient  Table 1 shows the average gestational age of the LISA group with less invasive technique was 29.1 ± 1.9 weeks. The average gestational age of the group using INSURE technique was 29.7 ± 1.6 weeks. The average gestational age of LISA group was lower than the INSURE group but the difference was not statistically significant, p = 0.07. Table 2 shows the birth weight in the LISA group was 1248.1 ± 311.6, lower than the birth weight in the INSURE group was 1308.5 ± 309.1. The difference is not statistically significant, p = 0.32. The smallest birth weight in the LISA group was 600g, the highest was 1800g. The smallest birth weight in the INSURE group was 800g, the highest in 1950g.      In addition, the gastric tube we use is hard enough to put directly into the trachea without using Magill pliers, simple technical manipulation. These are the advantages of a technique.
Simple equipment easy to find, low cost and simple operation easy to carry out. There was no difference between the two groups in the study of primary features or prenatal risk factors, except that the was not statistically significant [11].
In the study of Bao et al. [8], the use of antenatal coticosteroids 2 groups INSURE and LISA group was 93% and 89.4%, the difference was not statistically significant p = 0.54 [12]. In the study of Mohammadizadeh Majid et al. [7], the use of antenatal coticosteroids in the INSURE group and the LISA group was 89.5% and 84.2%, p = 0.2 [13]. In our study, the rate of adequate use of antenatal corticoids was lower than that of other studies but no difference was found between the two LISA groups and the INSURE. The use of antenatal corticoids for pregnant women at risk of preterm birth contributes to improved adverse outcomes for preterm neonates.
The effect of antenatal corticoids reduces the incidence and severity of respiratory endothelial respiratory depression in preterm neonates. In a Systematic review of Robert D 2017 on the Cochrane Library, treatment with prenatal corticosteroids (compared to placebo or no treatment) was associated with a reduction in the most serious adverse outcomes associated with preterm birth,

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