Microbial Endocrinology: Interaction of the Microbial Hormones with the Host

Recent studies of the human microbial ecology, studying the communities of bacteria within the human bodies. The genetic information of the bacteria within the human bodies can be 150-fold greater than the human genome. A complicated interaction between the host and the microbial gut. Indeed, the gut microbiota plays important roles in host metabolism, immunity and even behavior. Mechanisms by which the microbiota are known to mediate these functions include breaking down dietary components, educating the immune system and degrading toxins [1-3]. In recent years modulation of hormonal secretion revealed the nature of the host bacteria interaction. Actually, direct after birth, bacterial colonizating the intestine perform by a critical role in the maturation of the immune system [2] and the endocrine system (Clarke 2013).

Neurohormones and Stress Hormones: Neurohormones are secreted from neuroendocrine cells in response to a neuronal input.
Although they are secreted into the blood for a systemic effect, they can also act as neurotransmitters. Modulation of behavior by the microbiota (such as anxiety in mice) is believed to occur through neurohormone precursors (e.g. serotonin, dopamine) (Lyte 2013).
Gut bacteria can produce and respond to neurohormones such as serotonin, dopamine and norepinephrine (Roshchina 2010).
The mice have elevated plasma levels of the stress hormones corticosterone and adrenocorticotropic hormone (ACTH) in response to mild stress [15,16], increasing behaviors associated with anxiety and stress. ACTH affect the hypothalamic-pituitaryadrenal axis by further producing corticosteroids. Accordingly, two specific species, L. helveticus and B. longum, reduce levels of the stress hormone cortisol and anxiety-like behavior in both rats and healthy humans [17]. Furthermore, mice chronically treated with the probiotic L. Rhamnosus had lower levels of corticosterone and less depressive behavior in a forced swim test than controls [18].
Pheromones and Sex Hormones: Pheromones are hormones that play important roles in sexual recognition, attraction and mating behavior as well as aggression behavior and dominance.
Pheromones are also termed ectohormones, chemicals secreted outside of the body of one individual and affect the behavior of others. Since four decades the effect of sex hormones on the bacteria has been reported . For instance, Prevotella intermedius takes up estradiol and progesterone, which enhance its growth [19]. The composition of the intetinal microbiota can be affected by the change in the nges in expression of the estrogen receptor, ER-β [20]. This interaction goes both ways, as several types of bacteria have also been implicated in steroid secretion or modification [21]. Clostridium scindens converts glucocorticoids to androgens, some male steroid hormones [21]. Adlercreutz et al. [22] reported that, use of antibiotic decreases the level of esterogen so intestinal bacteria play a role in estrogen metabolism. The levels of urinary estrogen and fecal microbiome richness, as well as presence of Clostridia, including non-Clostridiales, and three genera within the Ruminococcaceae suggested a kind of correlation.

Feeding and Metabolism:
A classic role of the gut microbiota is in digesting a variety of carbohydrates and fermenting them into short-chain fatty acids (SCFAs). For example, subtherapeutic doses of antibiotics, which do not eliminate the gut microbial community but rather cause significant changes in its composition, lead to increased levels of SCFAs and to weight gain in mice [23]. This effect can extend to the levels of the glucose and the triglyceride.

Immune System and Immune Responses
Many evidences linked both hormones and the microbiome to immune responses under healthy conditions and autoimmune disease (AD). The intestinal microbiome has an impact on immune system development and differentiation. It is well known that the microbiome affect the initiation and progression of infectious diseases [24]. Th gut microbiota can send signals to stimulate the normal development of the immune system and the maturation of immune cells (Louis 2014). The gut bacteria stimulates the secretory IgA response that is involved in inactivating rotaviruses, competes Clostridium difficile colonization, and neutralizes cholera toxin [25]. There are many interconnections that the microbiome and hormones may affect the immune system through shared pathway.
The immune and neuroendocrine systems share a common group of hormones and receptors. Glucocorticoids such as corticosterone and cortisol regulate inflammation levels and have effects both on the innate and adaptive immune responses [26].