Silicone Implants Biocompatibility after Latissimus Dorsi Flap Reconstruction

Main Body: The major objective of this study to investigate Capsular Contracture (CC) which remains a concern in long-term transplantation and most common complications following silicone implants placement after Latissimus Dorsi flap (LDF) breast reconstruction surgery. CC formation, with special attention paid to immunological and inflammatory reasons, estrogen receptors in peri-prosthetic tissue development, as well as actual prophylactic strategies after breast reconstruction surgery were all investigated. This review summarizes and explores these trends of the association between conflicts of interest and study outcomes in oncoplastic surgery. In addition, we explored whether studies have identified microbial biofilms on various implantable materials and Foreign Body Reaction (FBR).


Introduction
First of all, breast cancer is an unpleasant and sometimes devastating event in a woman's life. The goal of oncoplastic breast surgery is restore the appearance of the breast and improve patient quality of life. To use of flap reconstruction of breast following mastectomy is considered by many surgeons as the gold standard [1]. Today, advances of this technique are that it is reliable, predictable, relatively easy to perform various contours and landmarks of the breast, which has resulted in improvement of aesthetic results [2]. The Latissimus Dorsi Musculocutaneous Flap (LDF) plays and important part of breast reconstruction history. This technique has been studied by many researches since its introduction by Iginio Tansini in 1896 [3]. Previous studies have reported, the great used of LD flap procedures in both the delayed or immediate reconstruction [4], with or without implants [5] and as procedure for small volume reconstructions [6]. This research extends our knowledge of the patients who is candidate for LDF, operation techniques, most common complications following breast reconstruction surgery and further investigation for the future concern. Breast reconstruction with flap is safe as total mastectomy for early-stage patients and even in stage III patients [7]. These findings suggest that LDF is the first line for obese patients [8] and the patients with insufficient abdominal fat [9], resistant to the deleterious effects of tobacco use and diabetes in wound healing, which makes it an excellent choice in these high-risk of necrosis and secure for reconstruction in the event of damage to the skin envelope [10].

Latissimus Dorsi Flap Postoperative Management
Debate continues about the best strategies for the management of operative technique positioning cushion and skin-sparing mastectomy [11], scar transparency [12], the flap transferring with preserved thoracodorsal nerve and artery [1,13]; simple and reliable nipple reconstruction with badge flaps combined intradermal tattooing for the nipple areola, which it gives the patient good psycho-logical support and provides a very good result aesthetically with an inconspicuous scar at the donor site [14]. Recently, researches have shown an increased interest in endoscopic-assisted LD flap transposition. This technique leaves less scarring on the back than conventional LD flap transposition [15] due to the limitation accessibility and difficulty of harvesting [16].
However, repositioning the latissimus dorsi muscle may result in moderate-to-severe postoperative pain [13]. This result may be explained by the fact of wound dehiscence, skin necrosis and seroma formation by damaging lymph vessels and inflammatory exudates caused by more extensive subcutaneous and muscle dissection [17].
The whole thickness of the muscle is mobilized and detached distally; attempts to spare some of it to retain function simply lead to atrophy from denervation [8,18]. Resulting from tissue oxygenation [19], hypertension and hyperlipidemia will lead to delay wound healing and vasopressors [20]. Pressure garments [21] or fibrin sealants; limited use of electrocautery, long-term drainage [22] will minimizing seroma formation. LD flap reconstruction can result in weakness and reduced mobility in shoulder function [23] within postoperative time, but in long term recovery detected near normal [24] with no significant loss of range of motion, strength, or pain in the shoulder at 1 year [14].

Implants Placement Complications
The main contribution of breast volume components are the LD muscle, its skin paddle, and in most cases use of silicone implant [25], which is placed under the muscle alone or with a tissue expander and to expand the skin to provide adequate skin coverage of the correctly sized implant [21]. Risk of bacterial infection, radiotherapy complications [6,10], chronic wound damage and inflammatory response [26], closely related to patient sensitivity to position of implant placement. Due to physiological inertness and low toxicity, silicone implants are biomaterials [27] that are frequently used in the medical industry. But according to some recent research, the most common fibrosis reaction is the Foreign Body Reaction (FBR) [28], which occurs when biomaterials are implanted. The fibrotic response to biomaterials is caused by an immune reaction, this occurs through adaptive immune reaction in 6 stages: a) Blood-biomaterial interaction is initialized by the leakage of blood at the wound site when an implant inserted and results in the surface bonding of proteins in the blood [29]. b) In provisional matrix formation high-affinity proteins (i.e., fibrinogen, kininogen, fibronectin, and vitronectin) combine to form a provisional matrix [30] various inflammatory cells (i.e., neutrophils, eosinophils, basophils and others).
The complex capsular factors determined capsular contracture grade incidence with covered polyurethane-or silicone-textured surface implants [5]. Therefore, the word "biocompatibility" has used to describe the overall biological innocuousness of silicone in the respective studies [36]. The hormonal status was recently linked to these processes as well, such as post-operative pregnancy to be a risk factor for capsular contracture. Estradiol is a potent mediator of angiogenesis: estrogen receptors are involved in the regulation of Vascular Endothelial Growth Factor (VEGF) pathways, induce TGF-β1 production and myofibroblasts differentiation [37].

Improving Satisfaction in Breast Reconstruction
According to the multiple studies, one method for improving postoperative skin flap-based complications in breast reconstruction is the use of Indocyanine Green (ICG) soluble dye angiography for real-time imaging and assessment of blood flow and tissue perfusion perioperatively. ICG is eliminated by the liver and excreted in bile [38]. The main reason of Indocyanine Green angiography use is predicting postoperative flap necrosis [39] and delayed wound healing through identification of hypoperfusion and debridement of compromised tissue [40]. Despite the higher stakes for potential necrotic skin flaps in expander-or implantbased reconstruction patients, especially for those with thinner mastectomy flaps, autologous reconstruction was associated with an increase in Indocyanine Green angiography use [41]. Last of all, patient expectations and the decision-making process play a key role in determining satisfaction with breast reconstruction following mastectomy [42]. The breast cancer conservative treatment cosmetic results (BCCT.core) provides an overall aesthetic assessment based on breast symmetry, skin color changes, and surgical scar appearance on photographs of women who have undergone breast-conserving surgery with or without radiotherapy [43]. The BREAST-Q is a newly developed, Patient- The hormonal status was recently linked to these processes. Each procedure is associated with specific potential complications and it is here where careful patient evaluation is necessary to choose the "right" procedure for the individual patient.