Patterns of Cataract in Patients Reporting to Christian Hospital, Taxila, Pakistan

Arnold Rafiq1 and Noureen Latif2* 1Hospital pharmacist at Christian Hospital, Taxila, Pakistan 2Lecturer at Sarhad University, Islamabad campus, Pakistan Received: October 25, 2017; Published: November 07, 2017 *Corresponding author: Noureen latif, Lecturer at Sarhad University, Islamabad campus, Pakistan, Tel no: ; Email: ISSN: 2574-1241 DOI: 10.26717/BJSTR.2017.01.000502 Noureen latif. Biomed J Sci & Tech Res


Introduction
Cataract is a haziness (clouding) of the eye lens that leads to a decrease or in severe condition loss of eye vision. One or both of the eyes can be affected by this condition. It does not develop at once rather it grows and develops slowly. Symptoms of this condition may be: fading of colors they may become discolored if prolonged b. Blurred or fizzy vision, c.
Corona around the light, d.
Trouble while sighting bright lights e. Difficulty in sighting in night [1].
All these symptoms can lead to difficulty car driving. This may result in trouble driving, book reading, perceiving or recognizing faces. Difficulty in vision increases the risk of falls and depression. Inherited.
Cataract is cause of blindness in about 5% of the population in America and twenty million throughout the world. In developing countries 10-40 children/100,000 suffer from cataract and in developed countries 1-4 children/100,000 [4]. Due to cataract it becomes tough to see in low light. It creates ring around dark lights. It may also become impressive to see. It creates a yellow or brown distort around anything that is viewed. It causes colors to become bleached. Cataract does not spread from one eye to another eye. The destructive eyesight evolves slowly. It takes time. Cataract becomes worse and worse if it is not treated. The severity of cataracts increases. It is rose complications on reading and writing. Surgery is wanted to eradicate the lens that is affected. Surgery also altered the affected lens. Cataract appears usually in the individuals of older age. It is very common in older individuals. Because of cataract, large numbers of people are facing blindness. It is at global level. The rate of blindness is increasing day by day [5]. There is no accessibility of surgery of cataract as spread more broadly. This is in the developing countries. It has been proposed that the number of blindness due to cataract has been reached more than 39 million [6].
It will be in the year 2025. This has been proposed by the recognizing of involvements that delay the evolvement or advancement of cataracts [7]. It has been also proposed by the projection of population. Surgical involvement is very limited in the developing countries [8]. This limitation of surgical involvement causes many troubles and complications in the treatment of cataract blindness. It has been proposed that cataract has become the third leading cause of blindness. It has become in the United States [9]. There is more than 8% of blindness in United States. The preponderance of blindness that occurred due to cataract was more than 13 per 100,000. The incidence of blindness occurred due to cataract was more than 1.5 per 100,000. It has been accounted in 1970. Due to operations of cataract, many influences have been occurred. It has been recorded that cataract reduced since 1970 in developed countries [10]. It has been recorded freshly that the leading cause of blindness is cataract due to non-operated age related cataract. It has been pointed that the influences in age related lens were more than 40% of people with the age from 52 to 64.
The preponderance of these influences increased to more than 90% for people age from 75 to 85. Age related cataract is ranged from 4% to 50% from the age 52 to 64 and 75 to 85 respectively [11]. Cataract appears in the people of age 65 which is rising to more than 60% in the age of 85 in United Kingdom. People with age 65 are suffering from cataracts. Its rate is 20%. It is 60% in the age 85 in France [12]. It has been expressed that the preponderance of cataract becoming doubles in Australia. It is becoming double with each decade of age after 40 years [13]. Almost every person with age 90 is facing cataract. Same incidence and preponderance of cataract has been expressed by the developed countries [14]. As the people are living long age so the preponderance of cataract is on the peak. It has become usual in these days. The record has been proposed freshly that cataracts appeared in more than 21 million adults of age 40. This rate will become double in year 2020 [15]. Data of incidence are accessible for cataract that is age related cataract. They are just few incidence data. The preponderance data of age-specific has been used by many to record incidence rates for lens opacities and for cataract for 5 years. The 5-year incidence records for ages, for lens opacities are as followed: a.
Age 55 was 10%, The 5-year incidence records for ages, for cataract, the corresponding incidence records were 1, 2, 5, 9, and 15% . These records show that the lens opacities are not revocable. They also shows that the lens opacities not attended by a differential mortality. The incidence rate reached to more than 80% for persons. The age is from 70 to 74 at baseline [17]. Age that is increasing is the major risk factor for age related cataracts. It has been proposed that the preponderance of cataract blindness increased. It has been also studied that the preponderance of cataract rose from 4% at age 52-64. It is 50% at age 75-85. More than 90% of person ages from 75 to 85 have age-related lens influences. The associated proof from many studies proposes a minor excess risk of cataract for women compared with men. An extensive risk of cortical cataract may describe the 10-20% excess risk of cataract among women [18]. It has been proposed that cortical and nuclear cataracts are more usually commence in blacks than whites. It has been proposed that cataracts are the leading cause of blindness in blacks.
It has been studied that an extensive preponderance of cataract in tropical regions compared with non tropical regions are complex to calculate due to variations in survey methodology [19]. However, preponderance rates modified for age. It has been proposed an almost threefold reach in the preponderance of cataract at a level of 185m compared with locations at more than 1,000m. In this study, due to tall neighboring mountains, extensive ascensions had less sunlight than lower ascensions. There was a strong positive combination between increasing hours of sunlight exposure and cataract [20]. Cataracts are the most common cause of destruct vision at global level. Cataracts particularly affect populations in evolving countries. They cause blindness. The study has been expressed in India that the preponderance of cataracts is three times greater than in the United States. The preponderance rate is 82% of Indians [21]. It is from the age 75 to 83 years. They are suffered by cataracts. In US only 46% of people are suffered from cataracts from age 75 to 83 years. It has been recorded that the cataract will increase in the evolving countries. The population increases will be the extensive. The people with the age 65 are increasing day by day. Due to the increase of this day by day, the incidence of cataract will appear. Then there will be surgery of cataract need [22].

Materials and Methods
It was a cross-sectional descriptive study done in Christian Hospital, Taxila Pakistan. The objectives of the study were to study the patterns of cataract, to find the causes of cataract and to collect the medical history of the patients. Study population was the patients reporting to Christian Hospital, Taxila. Convenient sampling technique was used to data collection. A self structured questionnaire was used as a data collection tool. Study duration was 2 months and sample size was n=120. A pilot study was done on 12 patients to assess the language and accuracy of the questionnaire. After that necessity changes were made in it and final questionnaire was designed. After collecting the data, all the variables were coded and data was entered in to SPSS version 20 software and was analyzed for the result. An informed written consent was taken from the participants before filling all the information on the questionnaire. A permission letter from the Christian Hospital, Taxila was taken before starting the study to collect data. Figure 1: Type of cataract diagnosed. 120 persons were interviewed on the basis of convenient sampling. n=31(25.85%) were females and n=89 (74.14%) were males. Mean age of the respondents was 74.5±.04 years. Minimum and maximum age was found to be 20 and 89 years respectively. Majority of the patients were of the age group of 60-79 years (n=68, 56.7%) and were illiterate (n=49 out of 120). n=84 (70.0%) belonged to low socioeconomic status. n=57 came to hospital due to poor vision in left eye, n=54 had poor vision in right eye and n=9 had poor vision in both eyes. Further results are given below (Tables 1,2).

Discussion
According to the financial Pakistan survey of blindness this medical condition is affecting 2-4.3% of Pakistani population. One of the main reasons of the blindness is the cataract. There are many reasons behind this condition. It can be age related in most of the cases, congenital and secondary to other causes. Surgery is the most effective and easy way to get rid of this situation and to stop visual impairment [23]. Progression to the aging process is highly linked to the development of cataract. In the present study majority of the respondents were suggested surgery and intra ocular lens was to be inserted in place of the cataract lens. Study done in Europe support the results of the present study which properly explain the total literature of the cataract and blindness and other complications related to the cataract [24,25]. Diabetics do not process glucose normally. The enzyme aldose reductase changes glucose to sorbitol through the polyol pathway. Sorbitol should be changed to fructose by the enzyme sorbitol dehydrogenase, but the sorbitol is produced faster than it can be converted to fructose, causing a buildup of sorbitol in the lens.
Accumulation of sorbitol leads to increased water within the lens, changing the lens fiber array and formation of sugar cataracts. Osmotic stress caused by the sorbitol accumulation 3 causes death of lens epithelial cells4 leading to the development of cataract. Increased glucose levels in the aqueous humor may cause chemical changes of lens proteins. This has negative effects upon the lens. Lenses of diabetics show an impaired antioxidant capacity, increasing the effect oxidative stress. For this reason, a healthy lifestyle to reduce the risk of developing diabetes over one's lifetime is highly recommended [26]. Smoking has been linked to cataract risk and is one reason eyecare practitioners have been more diligent to discuss smoking cessation with patients. One study reported that anyone with a history of smoking cigarettes was associated with an increased risk of age-related cataract. Current smokers had a higher risk of incidence. They found that former and current smokers were associated with nuclear and sub-scapular cataracts. Recently, another study found a significant dose-response relationship between smoking and the need for cataract extraction. Conversely, smoking cessation was associated with a decrease in risk that accumulated over time [27].
Various types of cataracts occur related to systemic disease. Inflammatory disorders causing uveitis may require recurrent use of topical or oral steroids. Common inflammatory disorders include ankylosing spondylitis, Crohn's disease, ulcerative colitis, juvenile idiopathic arthritis, Behçet's syndrome, and sarcoidosis. Repeated treatment of allergies using oral steroids or chronic use of topical or inhaled steroids may also cause posterior sub-scapsular cataracts in a presenile patient. Neurofibromatosis, a genetic disorder causing tumors to form on nerve tissue, is associated with cataract formation, as is Wilson disease, an inherited disorder associated with copper accumulation in the liver, ocular tissues, and other organs. Cataracts are now associated with syndromes such as Cohen syndrome, Degos disease, and Dubowitz syndrome. In some cases, the formation of cataracts may lead to initial diagnosis of a systemic condition [28,29]. Traumatic cataracts Trauma may result in clouding of the lens. Injury may be directly to the eye or indirectly, as seen with head trauma. It may be blunt or penetrating trauma, or it may be related to radiation exposure.
Changes may occur years or decades after the injury, and diagnosis is often made based upon appearance even if the patient is unable to report a traumatic event. A monocular, presenile cataract is a telltale sign of trauma. Blunt trauma is associated with a characteristic rosette or stellae-shaped opacification and often involves the posterior capsule. Penetrating injuries typically directly compromise the lens capsule, leading to cortical opacification at the injury site. Ocular surgery may also induce cataract formation.
Retinal surgery, such as scleral buckling and vitrectomy, may result in presenile cataracts. To prevent blindness due to cataract routine medical checkups should be done. To prevent the further eye damage, risk factors should be controlled. Smoking should be avoided and diet high in anti-oxidants and carotenoids should be taken to prevent cataract in old age.

Conclusion
In the present study most of the respondents were suffering from age related cataract. Nuclear cataract was more prevalent among them. Majority of the patients had gone through the surgery and were facing difficulty in walking.