Attempts at the Creation of a Prosthetic Venous Valve in the Treatment of Chronic Venous Disease

Yolanda Bryce*, Sharath Kumar and Paul Booth

Received: November 21, 2018;   Published: December 20, 2018

DOI: 10.26717/BJSTR.2018.12.002509

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Abstract

Chronic Venous Disease (CVD) affects more than 25 million people with 20% of patients developing the most severe form of disease of large gaping nonhealing leg wounds with skin break down and exudative ulceration (Figure 1) [1,2]. CVD is caused by irreversible damage to the venous valves (one-way valves that promote the one-way flow of blood from the legs to the heart and inhibit blood from pooling at the ankles and causing venous hypertension) leading to varicose veins, leg pain, swelling and leg ulcers and wounds [2]. Risk factors include prior Deep Venous Thrombosis (DVT), hereditary disorder, prolonged standing/sitting, and obesity [2]. The prognosis of venous ulcers is poor with delayed healing and recurrence. Annually, an estimated $3 billion are spent in the treatment of chronic venous wounds [3].

Abbreviations : CT: Computed Tomography; ICA: Internal Carotid Artery; MRI: Magnetic Resonance Imaging; VZV: Varicella Zoster Virus; HSV: Herpex Simple Virus; CSF: Cerebro Spinal Fluid