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OpinionOpen Access

Current Challenges and Future Perspectives for Applying Biologically Synthesized Magnetic Nanoparticles for Human Health Benefit

Volume 11 - Issue 3

Gabriele Vargas and Fernanda Abreu*

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    • Instituto de Microbiologia Paulo de Góes, Brazil
    • *Corresponding author: Fernanda Abreu, Instituto de Microbiologia Paulo de Góes, Brazil

Received: November 15, 2018;   Published: November 26, 2018

DOI: 10.26717/BJSTR.2018.11.002091

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Abstract

In modern science, nanoparticles are considered the next-generation tools of biotechnology. Among the diverse qualities of nanoparticles, the interest of the scientific community in magnetic nanoparticles has always been eminent because of the possibility of manipulating these structures by a magnetic field. Magnetic iron oxide nanoparticles are one of the most relevant tools for biotechnology, and these are usually synthesized by chemical methods. A recent and environmentally friendly method to produce biocompatible magnetic nanoparticles is achieved by the growth of magnetotactic bacteria in large scale. Many advantages of using the biologically synthesized nanoparticles have already been showed, including their higher efficiency on drug delivery and on killing tumors by hyperthermia. Therefore, new proposals for the treatment of human diseases using biologically synthesized nanoparticles are growing in the last few years. In the meantime, discussion about the necessary steps to enable the use of these nanoparticles in health treatments is relatively near to the ground. Here we emphasized future challenges to the use of magnetic nanoparticles in biomedicine and proposed alternative tests to complement research dedicated to the evaluation of new biomedical applications on this subject.

Keywords : Magnetic Nanoparticles; Magnetosome; Fe3O4; Iron Oxides; Biomedicine; Biotechnology; Cytotoxicity

Abbreviations : MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; LDH: Lactate dehydrogenase

Introduction| Conclusion Acknowledgment References|