*Corresponding author:
Amirmorteza Ebrahimzadeh Namvar, Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, IR IranReceived: August 18, 2018; Published: August 31, 2018
DOI: 10.26717/BJSTR.2018.08.001675
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Introduction:Acinetobacter baumannii in the past two decades is known as one of the problematic acquired pathogens in hospitals. The capability of these bacteria in causing multiple diseases is due to emergence of multi-drug resistance strains and compatibility with medical equipments. Aminoglycosides are one of the first-choice drugs used to treat infections caused by A. baumannii strains; however, resistance to aminoglycosides has been developed recently.
Aim: This study aimed to trace prevalence of aminoglycoside modifying enzymes in Acinetobacter baumannii isolates.
Materials and Methods: In this descriptive study, a total of 52 A. baumannii strains isolated from patients of Ayatollah Rouhani and Shahid Beheshti hospitals from Babol. After confirming, an antibiotic susceptibility test was conducted using disc diffusion method. Thereafter the prevalence of aminoglycoside modifying enzymes such as aacC1, aphA6 and aadA1 were analyzed using polymerase chain reaction method.
Results: Amongst 52 isolates, the most resistance was observed in kanamycin, piperacillin, chloramphenicol, rifampicin, cefixime and cefotaxime, also the most sensitivity was belonged for colistin. Moreover, the frequency of aminoglycoside modifying enzymes genes was achieved for aacC1 52(100 %), aphA6 51(98.07%) and aadA1 40(92.72%).
Conclusion: The results of this study showed a significant prevalence of genes encoding aminoglycosides modifying enzymes in Acinetobacter baumannii isolates in the studied region. Therefore, it is important to be concern about the extensive monitoring of antibiotic resistance and the prevention of the emergence of multi drug resistance strains.
Keywords: Acinetobacter Baumannii; Aminoglycoside Modifying Enzymes; Multi Drug Resistant Strains; PCR; Pseudomonas Aeruginosa; Immunocompromised; Spectrum Penicillins; Cephalosporins; Carbapenems; Fluoroquinolones; Chloramphenicol; Tetracyclines
Abstract | Introduction | Materials and Methods | Results | Discussion | Conclusion | Conflict of Interest Statement | Funding/support | References |