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Research ArticleOpen Access

Effects of S-Allyl Cysteine on Insulin Secretion: A Proposed Mechanism for its Anti-Hyperglycemic Effects

Volume 6 - Issue 3

Mashkoor Ahmed Ansari1, Ashique Ali Arain*2, Qumar Zaman Phull3 and Abdul Rahim Memon4

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    • 1 Department of Pharmacology, Bhittai Dental College MPS Sindh, Pakisthan
    • 2Consultant Family Physician, Assistant Professor, Department of Pharmacology, Isra University Hyderabad
    • 3Assistant Professor, Department of Pharmacology, Bilawal Medical College Jamshoro, Hyderabad
    • 4Department of Pharmacology, Isra University, Hyderabad

    *Corresponding author: Ashique Ali Arain, Consultant Family Physician, Assistant Professor, Department of Pharmacology, Isra University Hyderabad

Received: June 27, 2018;   Published: July 06, 2018

DOI: 10.26717/BJSTR.2018.06.001352

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Background: World is now moving towards the natural therapies due to many reasons not the topic of discussion. Majority of the available allopathic drugs are derived from the natural primary sources either from the animals or plants. Garlic and its derivative have been tested for many illnesses like hyperlipidemia, anti-platelet aggregation and HTN the current study focused on exploring the mechanism of glucose lowering properties of the S-allylcysteine, a garlic derivative.

Methodology: Rats were randomly divided into 3 groups with 10 rats in each group A was +ve control with no intervention, group B was kept –ve control given alloxon to induce hyperglycemia only, group C was given alloxon and S-allylcysteine . Blood sample were drawn after 7, 14 and 21 days to assess glucose random levels and plasma insulin concentrations. SPSS version22 using ANOVA as statistical technique was applied for data analysis.

Results: There was a significant reduction in blood glucose levels from 300+81.3mg/dl 364 +43.16and 218.+36.38mg/dl in S-allylcysteine treated group at 7, 14 and 21 days respectively with p-value 0.0001. Similarly serum insulin levels were also improved from3.87+2.16, 8.0+1.6and 11.5 +1.69U/Lin s-allyl cysteine group p-value 0.000021.

Conclusion: Alloxon induced hypo-insulinemia was successfully corrected by S-allyl cysteine fitting it into insulin secretogogue category.

Keywords: Hyperglycemia; Alloxon; Insulin; SAC; Insulin Secretion; Vitamin B12; GI diseases; Glibenclamide; Non-Interventional; Anti-Metastatic; Insulin Resistance

Abstract| Introduction| Methodology| Results| Discussion| Conclusion| Recommendations| References|