*Corresponding author:Alen J Salerian, Institution Modern psychiatry, ZAIMI 8, Paleo Falero, 17562, Athens Greece, Tel: 306983723947; Email: firstname.lastname@example.org
Received: May 11, 2018; Published: May 16,2018
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This study provides scientific evidence to suggest that human cells may transform to microorganisms and represent an independent source of some infections. Evidence consistent with the 99.9% probability of this hypotheses to be correct is presented.Two questions ”Do 38 trillion microorganisms that live in human bodyalways come from outside ?” and “ Do host cellshave the essentials totransform to microorganisms ?” prompt a reviewof genetic, epidemiological , biological and clinicalobservationsin support of thecentral hypotheses.The followingtenobservations are of essence
a) Host cells do have the essentials to produce microorganisms.
b) Human cells transform to other cells such as cancer and stem cells.
c) Rare scavenger microorganisms unelated to normal flora are crucial in corpse decomposition.
d) Opportunistic infections by microorganisms of higher geneticcomplexity emerge upon severeinjuries causingmassivecellular regeneration and death.
e) Aspergillus fumigatus grow in abundancein organic matter such as decaying leaves. andin the outdoor air oflarge scale compostingof sewagesludge factories.
f) Pseudomonasaeruginosaa common cause of opportunistic infections -have larger genome size and higher genetic complexity.
g) Genetic influences play an important role in some infections in immunocompetenthosts.
h) Some infections emerge without host to host transmission.
i) Extraordinary stress from diverse origins may trigger transformation of human cells to microorganisms consistent with the proven link between diverse infections, disorders and changes in host bacterial community.
j) Most reactions on earth are bi-directional. The Implication of theobservation that human cells may transform to bacteria or fungusare:
i. Some infections may be caused by human cells transforming to microorganisms.
ii. Some opportunistic and nosocomial infections may represent transformation of human cells to virulent microorganisms.
iii. Prevention and treatment of infections should address possible transformation of bacteria from human cells.
iv. Experimental validation of the central hypotheses is necessaryandmight bedemonstrated by experimental transformation of stressed or dying human cells to microorganisms.
Keywords: Bacteria; Transformation; Infection