Mini ReviewOpen Access

Energy and Skeletal Muscle Protein Metabolism Balance and Weight Loss in Patients with Alzheimer’s Disease: a Mini-Review

Volume 3 - Issue 5

**Tomiyo Nakamura*¹ and Nobuko Amano²**

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- ¹Department of Food Sciences and Human Nutrition, Faculty of Agriculture, Ryukoku University, Japan
- ²Department of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women’s University, Japan
*Corresponding author: Tomiyo Nakamura, Faculty of Agriculture, Ryukoku University, 1-5 Yokotani, Seta Oe-cho, Otsu, Shiga 520-2194, Japan

Received: April 09, 2018; Published: April 17, 2018

DOI: 10.26717/BJSTR.2018.03.000967

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Abstract

Weight loss is frequent in patients with Alzheimer’s disease (AD), even in early disease stage [1]. Therefore, weight loss is a significant predictor of mortality in AD patients. The etiology of AD-associated weight loss is multifactorial, occurring when energy expenditure exceeds energy intake [2]. In addition, the loss of skeletal muscle protein, one of the causes of weight loss, occurs by an imbalance between the rate of protein synthesis and degradation [3]. Therefore, many studies have examined energy expenditure, energy intake, body composition, and other genetic factors in relation to weight loss in AD patients. This mini-review further discusses the factors leading to weight loss in AD patients.

Keywords: Alzheimer’s Disease; Weight Loss; Energy Expenditure; Energy Intake

Introduction| Conclusion| References