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Topical Administration of Autologous Prothrombin at Sites of Bone Allografts Might be Helpful in Promoting Bone Healing after Bone Allograft Transplantation

Volume 3 - Issue 5

**Haibo Lu^1,2,3, Shibi Lu³ Wenjing Xu³, Jiang Peng³, Aiyuan Wang³, Quanyi Guo*³, Yong Luo¹, Chenyang Nie¹ and Sen Li¹**

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- ¹Department of Clinic Medicine, Hospital of People’s Liberation Army Hong Kong Garrison, China
- ²Department of Orthopaedics, First Affiliated Hospital of Chinese PLA General Hospital, China
- ³Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, China
*Corresponding author: Quanyi Guo, Institute of Orthopedics of Chinese PLA, Chinese PLA General Hospital, Beijing, China

Received: April 03, 2018; Published: April 12, 2018

DOI: 10.26717/BJSTR.2018.03.000957

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Abstract

Most of prothrombin initially located within allograft bone matrix is removed or destroyed by deep-freezing, freeze-drying and gamma irradiation. Prothrombin is an inactive precursor to thrombin, a key factor which can promote bone healing. Therefore, we hypothesis that topical administration of autologous prothrombin at sites of bone allografts might be helpful in promoting bone healing after bone allograft transplantation and suggest appropriate amount of venous blood be harvested to concentrate autologous prothrombin before bone allograft transplantation.

Keywords: Prothrombin; Bone Allograft; Bone Healing; Deep-Freezing; Freeze-Drying; Gamma Irradiation

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