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Review ArticleOpen Access

Role of Matrixmetalloproteinases in Periodontal Disease - A Review

Volume 2 - Issue 1

Navjot Kaur Parmar, Nisha KJ*, Sanjeela Guru and Shyam Padmanabhan

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    • Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, India

    *Corresponding author: Dr. Nisha KJ, Dept. of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, EPIP Zone, Whitefield, Bangalore, Karnataka, India

Received: December 19, 2017;   Published: January 05, 2018

DOI: 10.26717/BJSTR.2018.02.000632

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Matrixmetalloproteinases (MMPs) belong to family of proteolytic enzymes that cause degradation of extracellular matrix macromolecules, including interstitial and basement membrane collagens, fibronectin, laminin and proteoglycan core protein by secreting enzymes in latent form; which later gets activated in the pericellular environment by disruption of a Zn++ cysteine bond. There is much evidence for the role of matrix metalloproteinases in the destructive processes of periodontal disease distinguishing them as a viable target for a chemotherapeutic approach. The use of a host modulatory agent such as a matrix metalloproteinase inhibitor can assist with conventional treatment for periodontitis and, when used adjunctively, can enhance and make clinical therapeutic responses more predictable in the more susceptible patient.

Keywords: Matrixmetalloproteinases; Periodontal disease; Inflammation

Abbreviations: MMPs: Matrixmetalloproteinases; ECM: Extracellular Matrix; GCF: Gingival Crevicular Fluid; IFMA: Immunofluorometric Assay

Abstract| Introduction| History| Classification of MMP| Domain Structure Of MMP| Modes of Action| Estimation of MMPs in Periodontal Disease| Role of MMP Inhibitors in Periodontal Disease| Conclusion| References|