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Research ArticleOpen Access

Effects of Pulsed Electromagnetic Fields on Peripheral Nerve Regeneration Using Allografts in Sciatic Nerve: An Animal Model Study

Volume 1 - Issue 6

Minoo Shaddel1, Payman Tavakoli*1 and Rahim Mohammadi2

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    • 1Department of Pathobiology, Faculty of Medicine, AJA University of Medical Sciences, Iran
    • 2Departments of Surgery and Diagnostic Imaging, Urmia University, Iran

    *Corresponding author: Payman Tavakoli, Department of Pathobiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran

Received: October 31, 2017;   Published: November 09, 2017

DOI: 10.26717/BJSTR.2017.01.000509

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Abstract

Current gold standard for the clinical treatment of severe peripheral nerve damage involves using an autologous nerve to bridge the defect in injured nerve. Effects of pulsed electromagnetic fields (PEMF) on nerve regeneration were studied using allograft in a rat sciatic nerve model. Thirty male white Wistar rats were randomized into three experimental groups (n = 10): Normal group, allograft group, and PEMF treated group. In normal group left sciatic nerve was exposed and after homeostasis muscle was sutured. In the allograft group the left sciatic nerve was exposed through a gluteal muscle incision and transected proximal to the tibio-peroneal bifurcation where a 10 mm segment was excised. The same procedure was performed in the PEMF group. The harvested nerves of the rats of allograft group were served as allograft for PEMF group and vice versa. The PEMF group the whole body was exposed to PEMF (0.3 mT, 2Hz) for 4h/day within 1-5 days. Behavioral testing, sciatic nerve functional study, gastrocnemius muscle mass showed earlier regeneration of axons in PEMF than in allograft group (p < 0.05). Whole body exposure to PEMF improved functional recovery and morphometric indices of sciatic nerve. PEMF could be considered as an effective, safe and tolerable treatment for peripheral nerve repair and may have clinical implications for the surgical management of patients after nerve allografting.

Keywords: Peripheral nerve repair; Sciatic; PEMF; Allograft

Abstract| Introduction| Material and Method| Results| Discussions| Conclusion| Acknowledgement| References|