*Corresponding author:
Suman Gehlot, College of Pharmacy, Dr. APJ Abdul Kalam University, Indore, IndiaReceived: October 14, 2017; Published: October 24, 2017
DOI: 10.26717/BJSTR.2017.01.000459
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The objective of this study was to design and evaluate oral sustain release drug delivery system for Cinnarazine using hydrophilic polymers such as and HPMC (K100M), PVP (K) batches. Four batches were prepared by using HPMC (K100M) in drug: Polymer ratio of 1:1, 1:1.5, 1:2, 1:3 and five batches using PVP (K) in ratios of 1:1, 1:1.25, 1:1.5, 1:1.75 and 1:2. Further formulation F9 was modified by varying the ratios of diluents i.e F10, F11, F12 and F13 to check the effect of diluents on drug release. Matrix tablets were prepared by wet granulation method and were evaluated. Among the formulations studied, formulation F9 containing HPMC K100M (1:2) showed sustained release effect for 20 h with cumulative percent release of 88% similar to that of the research listed drug. The kinetic treatment showed that the optimized formulation follow first order kinetic with release exponent (n) 0.579 and having good stability as per ICH guidelines. Key Words: Sustained release, Hydrophilic gums, HPMC (K100M)/ (PVP (K), Magnesium stearate, Lactose and drug Cinnarazine.
Keywords : Sustain release; Matrix tablet; Cinnarazine
Abbreviations : DSC: Differential Scanning Calorimetry; FTIR: Fourier Transform Infrared
Abstract| Introduction| Pre-Formulation Study| Methodology| Result and Discussion| Conclusion| References|