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Review ArticleOpen Access

A Conceptual Review on Micro Bubbles

Sankha Bhattacharya1, Bhupendra G Prajapati2* and Arindam A Paul3

DOI: 10.26717/BJSTR.2017.01.000193

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    • 1Department of pharmaceutics, ROFEL Shri G M Bilakhia College of Pharmacy, India
    • 2Department of Pharmaceutical Technology, Ganpat University, India
    • 3Principal, ROFEL Shri G M Bilakhia College of Pharmacy, India

    *Corresponding author: Bhupendra G Prajapati, Associate Professor, Dept. of Pharmaceutical Technology, Ganpat University, Ganpat Vidyanagar, Mehsana, Gujarat-384012, India

Received: July 03, 2017;   Published: July 14, 2017

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Abstract

Microbubbles system is a newly invented non-invasive technique in which, in the presence of ultrasound waves or harmonic sounds micropores shrinks and agitated to produce micro bubbles within the applied area. These bubbles have the capability to target any perfused tissues within our body. Recently it was postulated that due to its narrow size range (1 to 10μm vesicular diameter) it can get easily engulf by phagocytic blood cells which can be very effective on lymphocytic cancer. Micro bubbles are prepared by using mechanical agitation, ultrasonication, pressurized gas-liquid mixing system etc. Micro bubbles are made up of a monolayer of protein shells, lipid shells, surfactant shells, polymer shells, Polyelectrolyte multilayer shells. Initially, microbubbles are used as diagnostic tools but due to its versatility of uses and properties of surface conjugation of proteins, genes, micro molecular nutrients, drugs slowly it’s becoming a therapeutic delivery tool. ALBUNEX® (GE Healthcare) was the first albumin conjugated micro bubble which was been approved by US-FDA. Recently importance is been given for brain targeting using Micro bubble carrier system. It was observed that using passive and active transport micro streamed bubbles can able to transport through Blood Brain Barrier (BBB). It is very important to give more importance to its stability and canonization of globules for more industrial acceptability.

Introduction| The Fundamental Challenges of Blood-Brain Barriers while Transporting Drugs| The Significance of Drug Transport within the Brain| Possible Competing Barriers for Drug Transport within the Brain Cells| Blood- Brain Barrier functions| New Insights of Microbubbles Drug Delivery System| Conclusion| References|